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Allergic disease only declining in pediatric talent allergy called atopic. Now many mothers worked, thus unable lactating fully during two years. So, babies given formula. On children who talented allergic, milk based formula cow milk could so originator occurrence allergy. allergic represents immune reactions deviating and raises symptoms adverse body. In body contains five types antibody or immunoglobulin, namely immunoglobulin G, A, M, E and D. Immunoglobulins E is antibodies much contribution on allergic reactions. In patient body allergies, there immunoglobulin E High grade, especially immunoglobulin E who specific against substances certain triggers allergic reactions, like dust, furs, powders flower or certain foods, like egg, milk and sea fish. Proteins cow milk can cause allergy who settled until end childhoods both in forms pure milk or another form. Son who allergic cow milk not always allergic beef. Symptoms typical on children who allergic cow milk are diarrhea with excreta bleed. If proteins cow milk already incoming into body, skin can reddish. Disturbance consequence allergy formula could arising because rapid reaction or emergence symptom under four hours. On slow reaction or new symptoms arising after exceeding four hours. Signs and allergy symptoms milk almost same with food allergy. Disturbance it can interfere all organs, especially digestion, skin and airway.

Many latest research disclose, disturbances gastrointestinal chronic with various mechanisms imunopatofisiologis and imunopatobiologis may disturb neurofungsional brain. Disturbance brain function it can affect disturbance behavioral, like less concentration, easy emotions, disturbances sleep, lateness talk, disturbances concentration, until aggravate symptoms hyperactive and autism.

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